The Tri-State Tornado of March 18, 1925 was the deadliest single tornado in U.S. history, killing 689 people in Missouri, Illinois and Indiana. The tornado caused devastating damage over three-and-a-half hours while traveling along its 219-mile long track. It raced through southeast Missouri, leaving death and destruction in Reynolds, Iron, Madison, Bollinger and Perry counties. This tornado also was the third-fastest tornado on record, traveling at nearly 60 miles per hour.